Sunday, November 9, 2008

Why study histology?

Why ask this question? It is true that most doctors seldom if ever look through a microscope after medical school. Some physicians and medical educators therefore regard the role of histology and microscopy to be marginal at best, if not altogether useless. Why should medical students take time away from obviously important topics to learn such an "irrelevant" skill?
Could the 17th century ecclesiastics who condemned Malpighi have been correct? Is "the anatomy of the exceedingly small, internal conformation of the viscera" of any real, practical use to a physician?
We hope so! Some physicians and medical educators cannot imagine becoming adequately educated in medicine without a rich perspective on tissue-level organization.
Many aspects of bodily function (e.g., inflammation, neoplasm) cannot be understood without such a histological perspective. Certain
diagnostic procedures depend critically on knowledge and skill at microscopic observation. And autopsy, complete with microscopic examination, still provides the "gold standard" for determining whether diagnosis and treatment have been appropriate. Expertise in histology (and histological pathology) is essential for thorough autopsy.
Unfortunately, routine
autopsy is growing unfashionable. Doing an autopsy incurs the risk of discovering that "mistakes were made" (e.g., incorrect or incomplete diagnosis, or inappropriate treatment). The easiest way to avoid such bad news is to omit the procedure, based on the economic rationale that routine autopsy represents an "unnecessary cost". Medical students are taught to consider costs as well as patient benefits before ordering any procedure. And, rather obviously, the procedure of autopsy cannot help the deceased patient; furthermore, it might even disturb members of the patient's family. However, without the potential discovery that autopsy can provide, mistakes may go undetected and corrective steps cannot be taken.
The real question concerning the mastery of histology is a matter of time. Do medical students have enough time to learn histology? Does any student have enough time to learn all the valuable knowledge and skills which can support the effective practice of medicine? If not, what then? Should one's training be broad and thin or deep but spotty? And, if spotty, what should be left out? No one knows the answers to these questions (although there are many strongly-held opinions).
Meanwhile, we proceed with the curriculum as it currently exists, including histology.

Here are several reasons to study histology.
Some of these are obvious, some are more subtle. Choose the reasons that work best for you.
· Because all knowledge is worthwhile, and/or because learning about the tissue composition of the human body is sheer joy.
· Because the perspective of histology can illuminate many other aspects of medicine, enriching and strengthing understanding in other areas.
· Because some of your patients might expect clear, accurate explanations of how and why their cells are misbehaving.
· Because someday you might become a pathologist, and histology interpretation is an essential clinical skill for a pathologist.
· Because someday you might need to communicate with a pathologist. Because you want to score well on the U. S. Medical Licensing Exam Next question: How should histology be studied?
The pleasure of learning is, for some, a fully sufficient motive for studying histology (or anything else). For others (i.e., for those who find remarkably little fun in histology), this is the weakest conceivable reason. In any case, this rationale applies equally well to any of the many delights available in the medical curriculum. It thus provides little guidance for budgeting one's study time.
It is impossible to appreciate the normal functioning of many organs -- such as lung or kidney or liver or brain -- without some detailed knowledge of how their cells are organized into tissues. In such cases, specific facts from histology provide essential strands in a web of understanding. And some important clinical processes, notably inflammation and neoplasm, are essentially tissue-level phenomena.
However, although a utilitarian rationale may appear quite solid for certain bits of histological information, the utility for many other bits may be indirect and more difficult to perceive.
Not all useful ideas are "critical" like each link in a chain. Understanding often has a structure more like a net, wherein interconnected ideas mutually reinforce one another and provide multiple routes of access to particular information. Although a chain fails if any link breaks, a net can function fairly well even if several strands are missing. This virtue of a net can only emerge from the presence of many interconnected strands. Any one strand may appear irrelevant or dispensible . . . but the more strands, the better. Adequate study of histology can provide several such strands.
Furthermore, the direct utility for much histology may not become apparent until after the best opportunity for study has passed. A rich understanding of histology helps sustain a deep appreciation of inflammation, tissue repair, and neoplasm ... but these clinically significant topics are currently deemphasized until theYear Two curriculum.

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